The Reds have been in impressive form early on this season, picking up wins away from home against Arsenal, Chelsea and Swansea City while Hull City and Leicester City could do nothing to stop heavy defeats at Anfield.
Jurgen Klopp’s side head into this massive game against Jose Mourinho’s Red Devils on the back of four straight league wins for the first time under the German.
With United dropping points at home to Stoke City just before the international break, it provides them with a big chance to make a statement to the rest of the prospective title challengers.
Should they beat Liverpool, Manchester United will join them on 16 points but could over take them with a high-scoring victory.
However, should the home side win by four goals to nil they could go top of the Premier League table after Manchester City dropped more points at home to Everton on Saturday.
That’s easier said than done, especially with injury concerns surrounding Georginio Wijnaldum and Adam Lallana, so how should Liverpool line up?
Have a look at the HERE to see how we think Liverpool should line-up against Manchester United.
1. GK: Loris KariusLoris
Karius has started Liverpool's last two Premier League games after returning from injury and looks set to remain Jurgen Klopp's first choice. Key stat: Karius has an 87% distribution success so far
2. RB: Nathaniel Clyne
Nathaniel Clyne looks to have overcome an injury to be fit to face Manchester United. Key stat: Clyne has created 14 chances in the top flight this season, more than all other defenders
3. CB: Dejan Lovren
Like Clyne, Dejan Lovren looks to have overcome a slight muscle problem and should be fully fit. Key stat: Lovren has won 17/26 headed duels so far this season
4. CB: Joel Matip
Joel Matip has settled into Liverpool's defence very quickly and already looks a nailed-on first-choice for Jurgen Klopp. Key stat: Matip has won 70% of his 10 attempted tackles this season
5. LB: James Milner
After shifting over to left-back this season, James Milner has adapted quickly and has been arguably Liverpool's best player. Key stat: All four of Milner's league goals this season have been penalties
6. CM: Jordan Henderson
Jordan Henderson has adapted well to his deep-lying role in midfield and should continue there vs Man Utd. Key stat: Prior to the weekend's action, Henderson had completed the most passes (508) in the league
7. CM: Emre Can
With Georginio Wijnaldum a huge doubt through injury, Emre Can will likely step back into midfield. Key stat: Emre Can won the most tackles (38) in the Europa League last season
8. CM: Adam Lallana
Adam Lallana missed the international break with a groin injury and he's a doubt to face United, but there's a feeling he will make it. Key stat: Lallana scored four league goals last season but already has three this term
9. LW: Philippe Coutinho
Philippe Coutinho played twice for Brazil in the international break but has extra time to rest ahead of their Monday night clash so should be fit Key stat: Coutinho has been directly involved in five goals this season; scoring 3, assisting two.
10. RW: Sadio Mane
Having played just once for Senegal during the international break and returning earlier than most players, Sadio Mane is fit and firing Key stat: Sadio Mane has a 71% shot accuracy this season
11. CF: Roberto Firmino
Roberto Firmino has shone for Liverpool as their lone striker this season and will continue in the role Key stat: No Liverpool player has scored more league goals than Firmino (13) since Klopp's appointment