Defensa y Justicia
Hugo Silva's 10th yellow card of the season will see a change in the back three with Mariano Bareiro most likely to make a return.
Alexander Barboza is coveted by Ariel Holan at Independiente, but will start at the heart of the defence.
Jonas Gutierrez continues in an unchanged midfield with Leonel Miranda and Gonzalo Castellani.
Emanuel Gigliotti won't be fit in time for Thursday so Ariel Holan looks set to either play Martin Benitez centrally or start Lucas Albertengo.
Nicolas Tagliafico will only arrive back in Buenos Aires on Wednesday after featuring for Argentina, but will be in contention to start in central defence.
Maxi Meza could start in a midfield three with Walter Erviti and Diego Rodriguez.
Defeat away to Sarmiento last time out was a first loss in nine matches with El Halcon conceding only a second goal in that whole period. Sebastian Beccacece's side may not have a lot of goals in them, but are defensively sound and tough to break down.
Ariel Holan had not lost as Independiente manager before the visit to La Bombonera and so El Rojo will be eager to bounce back from that disappointing defeat. If captain Nicolas Tagliafico is missing, the visitors will be far more vulnerable.
Both sides are ordinarily solid defensively and look to play on the counter so it will likely be a cagey meeting in Florencio Varela. However, Ariel Holan will know this Defensa y Justicia side well and with the motivation of Copa Libertadores qualification, El Rojo may just edge it.
Prediction: Defensa y Justicia 1-2 Independiente
FT OVER 2.5