New England Rev.
The New England Revolution will play in a diamond formation, which means Juan Agudelo will transition into a forward when his side move into attack.
Jay Heaps has a full squad to choose from for his side's first home match.
Cristian Higuita, Rafael Ramos and Kevin Alston are all injury concerns for Orlando City ahead of their first away game of the season.
Carlos Rivas will partner Cyle Larin up front in a new formation.
Kaka will miss out for Orlando City after sustaining an injury in the opening game of the season.
The New England Revolution suffered a disappointing opening day defeat to the Colorado Rapids and will now look to make amends. The Revs tend to be stronger at home and they must show that this weekend.
Last weekend was a momentous one for Orlando City. They opened their new stadium with a win over NYCFC and will now look to build on that against the New England Revolution.
Orlando looked strong on opening weekend and will be many people's favourites to claim three points.
Prediction: New England Rev. 1-2Orlando City